Research:
The North lab seeks to understand molecular and cellular basis of development and aging, and to identifying how deregulation in development, tissue homeostasis, and aging, increases our susceptibility to disease. In particular we are interested in how protein abundance and function is controlled through protein homeostasis mechanisms, and how those pathways change with age and contribute to disease. We use a combination of biochemical, molecular, cellular, and organismal approaches, with cell culture and mice as our primary model systems. Currently, our major goals are to define how tissues develop, maintain homeostasis, and age and to understand why aging is the greatest risk factor for disease, as well as to identify pathways to target for disease prevention and treatment.
Current areas of interests:
Current areas of interests:
- Regulation of tissue development, homeostasis, and aging by BubR1.
- Elucidating the mechanisms controlling the decline in BubR1 with age.
- Defining the molecular basis for aging as a risk factor for cancer, heart disease, and chronic wounds.
