Research:

The North lab seeks to understand molecular and cellular basis of ageing, and identifying how the process of aging increases our susceptibility to disease. In particular we are interested in how protein abundance and function is controlled through protein homeostasis mechanisms, and how those pathways change with age and contribute to disease. We use a combination of biochemical, molecular, cellular, and organismal approaches, with cell culture and mice as our primary model systems. Currently, our major goals are to define how organisms age and to understand why aging is the greatest risk factor for cancer, as well as to identify pathways to target for disease prevention and treatment.
 
Current areas of interests:

1. Defining the molecular basis for aging as a risk factor for cancer.
2. Elucidating the mechanisms controlling the decline in BubR1 with age.
3. Understanding the role of E3 ubiquitin ligases in aging and disease.
4. Effects of aging on cardiac conduction.

   © 2019 The North Lab