Publications:
Click here for a full list of publications
Selected Publications:
Renju Pun, Ann Cavanaugh, Emily Aldrich, Olivia Tran, Justin C. Rudd, Laura A. Hanson, and Brian J. North. (2024) PKCµ promotes keratinocyte cell migration through Cx43 phosphorylation-mediated suppression of intercellular communication. iScience. 27:109033.Yang Gao,
Renju Pun, Michael H Kim, and Brian J. North. (2023) Role of Connexin 43 phosphorylation on Serine-368 by PKC in cardiac function and disease. Frontiers in Cardiovascular Medicine. 9:1080131.
Jing Liu, Collin Tokheim, Jonathan D. Lee, Wenjian Gan, Brian J. North, X Shirley Liu, Pier Paolo Pandolfi, and Wenyi Wei. (2021) Genetic fusions favor tumorigenesis through degron loss in oncogenes. Nature Communications. 12:6704.
Niti Kumari, Somrudee Reabroi, and Brian J. North. (2021) Unraveling the molecular nexus between GPCRs, ERS and EMT. Mediators of Inflammation. 2021:6655417.
Celia Bloom and Brian J. North. (2021) Physiological relevance of post-translational regulation of the spindle checkpoint protein BubR1. Cell Biosciences. 11:76.
Naoe T. Nihira, Xia Bu, Chen Chu, Jinfang Zhang, Aleksandra Kolodziejczyk, Yizeng Fan, Ngai Ting Chan, Leina Ma,Jing Liu, Dong Wang, Xiaoming Dai, Huadong Liu, Masaya Ono, Akira Nakanishi, Hiroyuki Inuzuka, Brian J. North, Yu-Han Huang, Samanta Sharma, Yan Geng, Wei Xu, X Shirley Lui, Lei Li,Yoshio Miki, Piotr Sicinski, Gordon J. Freeman, and Wenyi Wei. (2020) Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nature Cell Biology.22:1064-1075.
Ying Ma, Danrui Cui, Xiufang Xiong, Hiroyuki Inuzuka, Wenyi Wei, Yi Sun, Brian J. North* and Yongchao Zhao*. (2019) SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation. Molecular Oncology. 13:307-321. * Co-Corresponding Author
Bin Wang, Zuliang Jie, Donghyun Joo, Alban Ordureau, Pengda Liu, Jianping Guo, Wenjian Gan, Jinfang Zhang, Xiangpeng Dai, Brian J. North, Yuhan Chen, Xuhong Cheng, Xiuwu Bian, Lingqiang Zhang, J. Wade Harper, Shao-Cong Sun, and Wenyi Wei. (2017) TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature. 545:365-369.
Naoe Taira Nihira, Kohei Ogura, Kouhei Shimizu, Brian J. North, Jinfang Zhang, Daming Gao, Hiroyuki Inuzuka, and Wenyi Wei. (2017) Acetylation-dependent regulation of Mdm2 oncogenic function. Science Signaling. 10:eaai8026.
Kouhei Shimizu, Hidefumi Fukushima, Kohei Ogura, Evan C. Lien, Naoe Taira Nihira, Jinfang Zhang, Brian J. North, Ailan Guo, Katsuyuki Nagashima, Tadashi Nakagawa, Seria Hoshikawa, Asami Watahiki, Koji Okabe, Aya Yamada, Alex Toker, John M. Asara, Satoshi Fukumoto, Keiichi I. Nakayama, Keiko Nakayama, Hiroyuki Inuzuka, and Wenyi Wei. (2017) The SCFbeta-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Science Signaling. 10:eaah4117.
Brian J. North, Michael A. Rosenberg, Karthik B. Jeganathan, Angela V. Hafner, Shaday Michán, Jing Dai, Darren J. Baker, Yana Cen, Lindsay Wu, Anthony A. Sauve, Jan M. van Deursen, Anthony Rosenzweig, and David A. Sinclair. (2014) SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO Journal. 33:1438-1453.
Brian J. North, and Eric Verdin. (2007). Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. Journal of Biological Chemistry. 282:19546-19555.
Brian J. North, Brett L. Marshall, Margie T. Borra, John M. Denu, and Eric Verdin. (2003). The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Molecular Cell. 11:437-444.
Selected Publications:
Renju Pun, Ann Cavanaugh, Emily Aldrich, Olivia Tran, Justin C. Rudd, Laura A. Hanson, and Brian J. North. (2024) PKCµ promotes keratinocyte cell migration through Cx43 phosphorylation-mediated suppression of intercellular communication. iScience. 27:109033.Yang Gao,
Renju Pun, Michael H Kim, and Brian J. North. (2023) Role of Connexin 43 phosphorylation on Serine-368 by PKC in cardiac function and disease. Frontiers in Cardiovascular Medicine. 9:1080131.
Jing Liu, Collin Tokheim, Jonathan D. Lee, Wenjian Gan, Brian J. North, X Shirley Liu, Pier Paolo Pandolfi, and Wenyi Wei. (2021) Genetic fusions favor tumorigenesis through degron loss in oncogenes. Nature Communications. 12:6704.
Niti Kumari, Somrudee Reabroi, and Brian J. North. (2021) Unraveling the molecular nexus between GPCRs, ERS and EMT. Mediators of Inflammation. 2021:6655417.
Celia Bloom and Brian J. North. (2021) Physiological relevance of post-translational regulation of the spindle checkpoint protein BubR1. Cell Biosciences. 11:76.
Naoe T. Nihira, Xia Bu, Chen Chu, Jinfang Zhang, Aleksandra Kolodziejczyk, Yizeng Fan, Ngai Ting Chan, Leina Ma,Jing Liu, Dong Wang, Xiaoming Dai, Huadong Liu, Masaya Ono, Akira Nakanishi, Hiroyuki Inuzuka, Brian J. North, Yu-Han Huang, Samanta Sharma, Yan Geng, Wei Xu, X Shirley Lui, Lei Li,Yoshio Miki, Piotr Sicinski, Gordon J. Freeman, and Wenyi Wei. (2020) Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nature Cell Biology.22:1064-1075.
Ying Ma, Danrui Cui, Xiufang Xiong, Hiroyuki Inuzuka, Wenyi Wei, Yi Sun, Brian J. North* and Yongchao Zhao*. (2019) SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation. Molecular Oncology. 13:307-321. * Co-Corresponding Author
Bin Wang, Zuliang Jie, Donghyun Joo, Alban Ordureau, Pengda Liu, Jianping Guo, Wenjian Gan, Jinfang Zhang, Xiangpeng Dai, Brian J. North, Yuhan Chen, Xuhong Cheng, Xiuwu Bian, Lingqiang Zhang, J. Wade Harper, Shao-Cong Sun, and Wenyi Wei. (2017) TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature. 545:365-369.
Naoe Taira Nihira, Kohei Ogura, Kouhei Shimizu, Brian J. North, Jinfang Zhang, Daming Gao, Hiroyuki Inuzuka, and Wenyi Wei. (2017) Acetylation-dependent regulation of Mdm2 oncogenic function. Science Signaling. 10:eaai8026.
Kouhei Shimizu, Hidefumi Fukushima, Kohei Ogura, Evan C. Lien, Naoe Taira Nihira, Jinfang Zhang, Brian J. North, Ailan Guo, Katsuyuki Nagashima, Tadashi Nakagawa, Seria Hoshikawa, Asami Watahiki, Koji Okabe, Aya Yamada, Alex Toker, John M. Asara, Satoshi Fukumoto, Keiichi I. Nakayama, Keiko Nakayama, Hiroyuki Inuzuka, and Wenyi Wei. (2017) The SCFbeta-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Science Signaling. 10:eaah4117.
Brian J. North, Michael A. Rosenberg, Karthik B. Jeganathan, Angela V. Hafner, Shaday Michán, Jing Dai, Darren J. Baker, Yana Cen, Lindsay Wu, Anthony A. Sauve, Jan M. van Deursen, Anthony Rosenzweig, and David A. Sinclair. (2014) SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO Journal. 33:1438-1453.
Brian J. North, and Eric Verdin. (2007). Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. Journal of Biological Chemistry. 282:19546-19555.
Brian J. North, Brett L. Marshall, Margie T. Borra, John M. Denu, and Eric Verdin. (2003). The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Molecular Cell. 11:437-444.
